解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Analgesic response, incidental pain and pain mechanism were evaluated in order to predict the chances of pain relief in advanced cancer patients. In an observation period of about 2 months, 130 patients were followed at home until death using only a pharmacological approach to control pain according to the WHO ladders...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90155-5
更新日期:1992-08-01 00:00:00
abstract::Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90165-8
更新日期:1992-08-01 00:00:00
abstract::The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90118-U
更新日期:1992-07-01 00:00:00
abstract::This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90110-W
更新日期:1992-07-01 00:00:00
abstract::In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(92)90241-3
更新日期:1992-06-01 00:00:00
abstract::The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90141-W
更新日期:1992-05-01 00:00:00
abstract::The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90152-2
更新日期:1992-05-01 00:00:00
abstract::The local anesthetic lidocaine was injected into the dentate gyrus (DG) of alert, unrestrained rats 10 min prior to investigation within the formalin test. Regional anesthesia of the DG resulted in a reduction of pain scores when administered contralateral to the site of subcutaneous formalin injection. The analgesic ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90195-H
更新日期:1992-04-01 00:00:00
abstract::Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90180-J
更新日期:1992-04-01 00:00:00
abstract::Ten patients with organic nerve injury causing chronic neuropathic pain were tested for the effects of intravenous lidocaine versus saline upon psychophysical somatosensory variables. The variables assessed were the subjective magnitude of pain, area of mechanical hyperalgesia and presence and magnitude of thermal hea...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(92)90087-R
更新日期:1992-03-01 00:00:00
abstract::This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90082-M
更新日期:1992-03-01 00:00:00
abstract::This study critically examines the reported exercise-induced analgesia effect in view of the potential stress-induced analgesia of pain testing itself. Two designs were used to test whether previous findings of analgesia were induced by the exercise procedures or by the stress of the pain testing procedures themselves...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90048-G
更新日期:1992-02-01 00:00:00
abstract::In rats anesthetized with sodium pentobarbital, we quantitatively analyzed descending modulation from the midbrain of a nociceptive flexion withdrawal reflex and responses of associated spinal neurons. We monitored the isometric force of hind limb withdrawal elicited by noxious heat stimuli (42-54 degrees C, 10 sec) o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90061-F
更新日期:1992-02-01 00:00:00
abstract::Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90054-F
更新日期:1992-02-01 00:00:00
abstract::Salmon calcitonin (s-CT) has been shown to be a valuable analgesic in phantom limb pain (PLP) in several case reports. To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe P...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90127-W
更新日期:1992-01-01 00:00:00
abstract::Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90229-Q
更新日期:1991-12-01 00:00:00
abstract::Despite many studies, the mechanisms underlying the pathogenesis of pain in cluster headache (CH) still remain obscure. An involvement of substance P (SP) containing neurons of the Gasserian ganglion and/or of the spinal trigeminal nucleus has recently been suggested, e.g., by impairment of inhibitory descending pathw...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90219-N
更新日期:1991-12-01 00:00:00
abstract::Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained im...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90218-M
更新日期:1991-12-01 00:00:00
abstract::Part I of our earlier pilot study demonstrated that patients preferred modulated stimulation forms - frequency modulation and burst - rather than conventional continuous mode. To assess whether long-term therapeutic effects validate the immediate test results, this trial was performed in 14 patients with 21 pain condi...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(91)90200-H
更新日期:1991-11-01 00:00:00
abstract::In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder. Both treatments resulted in a statistically significant ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(91)90007-K
更新日期:1991-10-01 00:00:00
abstract::We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(91)90109-B
更新日期:1991-09-01 00:00:00
abstract::The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90073-7
更新日期:1991-08-01 00:00:00
abstract::The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90078-C
更新日期:1991-08-01 00:00:00
abstract::The effects of lateral reticular nucleus (LRN) stimulation on the responses to tooth pulp (TP) stimulation of neurons located in the trigeminal (V) sensory (39 units) and motor (33 units) nuclei were assessed in anesthetized rats. Only neurons which responded to TP stimulation with bursts of spikes that were in a cons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90035-V
更新日期:1991-07-01 00:00:00
abstract::An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90055-3
更新日期:1991-06-01 00:00:00
abstract::We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90179-2
更新日期:1991-05-01 00:00:00
abstract::The blood vessels and the pial surface of the brain, spinal cord and its roots are innervated by primary afferent neurones. Here, we have electrophysiologically characterized the functional properties of a subpopulation of these afferent fibres that supply the ventral roots of the cat sacral spinal cord. We have taken...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90167-V
更新日期:1991-04-01 00:00:00
abstract::When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90166-U
更新日期:1991-04-01 00:00:00
abstract::This study records the consistency of transcutaneous electrical nerve stimulation (TENS) pulse frequency and pulse pattern used by 13 chronic patients over a 1 year period. The results show that patients prefer specific pulse frequencies and pulse patterns unique to the individual and that they turn to such frequencie...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90090-K
更新日期:1991-03-01 00:00:00
abstract::Capsaicin has been used extensively as an experimental tool and in traditional and proprietary topical medications for acute soft tissue injuries. More recently it has been prescribed for several chronic pain conditions where it is usually administered topically for periods of several weeks. Here we have studied the c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90101-3
更新日期:1991-03-01 00:00:00
abstract::Caffeine is frequently added to mild analgesic preparations but its effect when used alone on pain has never been studied in humans. Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(91)90129-L
更新日期:1991-02-01 00:00:00
abstract::Although several studies have shown that spouses of chronic pain patients may experience clinically significant depressive symptoms few studies have comprehensively examined the role of both patient and spouse-related factors in the development and maintenance of this emotional distress. Twenty-nine married male chron...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90148-Q
更新日期:1991-01-01 00:00:00
abstract::The associative network theory of memory [2] is outlined along with the concepts of mood congruity and state dependent learning. Two experiments are reported which investigate the occurrence of these effects where memory for pain is concerned. In experiment 1 the performance of 25 chronic pain patients was compared wi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91072-Q
更新日期:1990-11-01 00:00:00
abstract::This study determined whether opiates alter vascular components of inflammation (hyperthermia, edema and plasma extravasation) in addition to the suppression of hyperalgesia. Rats were administered carrageenan into one hind paw and saline into the other hind paw, followed by i.p. injection of morphine (0.2-5.0 mg/kg) ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90054-H
更新日期:1990-10-01 00:00:00
abstract::Locus of control (LOC) beliefs, long thought important in adjustment to persistent pain, were studied among 160 subjects (67 males and 93 females) referred to a comprehensive pain rehabilitation program. The subscale structure of the Multidimensional Health Locus of Control (MHLC) was factorially replicated in our sam...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91141-5
更新日期:1990-09-01 00:00:00
abstract::The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91167-H
更新日期:1990-08-01 00:00:00
abstract::Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91093-X
更新日期:1990-07-01 00:00:00
abstract::An electrophysiological study was carried out in anesthetized rats to characterize the properties of single neurons in trigeminal (V) subnucleus caudalis. Each neuron was functionally classified in terms of its cutaneous mechanoreceptive field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90010-B
更新日期:1990-06-01 00:00:00
abstract::Altogether 553 children (195 first graders, mean age 6.8 years, and 358 third graders, mean age 8.7 years) participated in the development of a self-report measure to assess the intensity of children's pain. The first step was the derivation, from children's drawings of facial expressions of pain, of 5 sets of 7 schem...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90018-9
更新日期:1990-05-01 00:00:00
abstract::The present study was undertaken to investigate the possible involvement of peripheral nociceptors in 3 diagnostic categories of elderly patients with chronic pain. The 3 diagnostic groups consisted of: chronic lower lumbar pain of degenerative musculoskeletal etiology (LLP), post-herpetic neuralgia (PHN) and pain of ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91104-Q
更新日期:1990-04-01 00:00:00